Letrozole and Height Increase in Adolescence

📈 Letrozole and Height Increase in Adolescence It's a well-established fact that estrogen and its receptors play a crucial role during puberty, particularly in the process of bone maturation. Letrozole, an aromatase inhibitor commonly used in breast cancer treatment, has shown potential in pediatric endocrinology as an off-label treatment for short stature. 

The mechanism is centered on its ability to slow the closure of the epiphyseal plates (growth plates). By inhibiting the aromatase enzyme, Letrozole reduces the conversion of androgens to estrogen, thereby delaying the fusion of these growth plates and allowing for continued bone growth and increased height. 

This treatment is only effective if the epiphyseal plates are still open. Once the growth plates have fused, Letrozole will not be effective in increasing height. 

This therapy should only be administered under the strict supervision of an endocrinologist.  The dosage used for growth is typically lower than the 2.5 mg used for breast cancer and may be administered for up to two years.

Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult with a qualified healthcare provider before considering any treatment.