The Power of Gly-NAC

The blend of Gly-NAC, a combination of glycine and N-acetylcysteine (NAC), holds immense importance. Both glycine and cysteine—derived from NAC—are precursors to glutathione, a master antioxidant in the body. By combining these two supplements, you can more effectively replenish your glutathione stores. 

 

This powerful mechanism helps to:

 

Reduce Oxidative Stress & Mitochondrial Damage: By boosting intracellular glutathione levels, Gly-NAC can effectively mitigate oxidative stress and protect your mitochondria. This, in turn, helps improve insulin sensitivity. 

 

Enhance Fatty Acid Oxidation: Surprisingly, this combination has been shown to improve fatty acid oxidation within the mitochondria, a function often associated with L-carnitine. This leads to increased production of acetyl-CoA, unlocking more energy for your body. 

 

Protect Against DNA Damage: Prolonged steroid use can cause significant DNA damage. The Gly-NAC combination can help prevent this by reducing plasma levels of H2AX, a type of histone that increases during steroid use. Histones are crucial for chromosome structure, and protecting them is key to preventing irreversible cellular damage. 

 

Boost Mitophagy: Gly-NAC can increase the expression of PINK1, thereby enhancing mitophagy (mitochondrial autophagy). This process is vital for regulating protein homeostasis and is a key area of research for preventing and treating diseases like Alzheimer's. 

 

Improve Endothelial Function: An added benefit, especially important during steroid cycles, is the reduction of plasma sICAM1 levels, which leads to improved function of your endothelial cells. 

 

Lower Triglyceride Levels: Significant reductions in triglyceride levels have also been observed. 

 

For optimal results, a daily intake of 3 grams of glycine and 1 gram of N-acetylcysteine is recommended. 

 

Finally, because of its ability to improve the pAMPK/AMPK ratio, Gly-NAC can be a valuable addition to your Post Cycle Therapy (PCT) regimen.