Sustanon 250
Active Substance: Sustanon 250
Description
What is Sustanon 250?
Sustanon 250 is an injectable, oil-based anabolic-androgenic steroid (AAS) that is a blend of four different testosterone esters. The "250" in the name refers to the total amount of testosterone esters in a single 1 ml ampoule, which is 250 mg. The four testosterone esters in Sustanon 250 are:
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Testosterone propionate (30 mg): A short-acting ester.
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Testosterone phenylpropionate (60 mg): A medium-acting ester.
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Testosterone isocaproate (60 mg): Another medium-acting ester.
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Testosterone decanoate (100 mg): A long-acting ester.
This unique combination of short, medium, and long-acting esters is designed to provide a sustained and steady release of testosterone into the bloodstream, which helps to maintain stable hormone levels over an extended period.
Sustanon 250 is primarily used in medical settings for hormone replacement therapy (HRT) in men with hypogonadism (a condition where the body does not produce enough testosterone). It is also sometimes used in supportive therapy for female-to-male transsexuals. Other names for Sustanon 250 include Sustanon Prolongatum and Durateston.
Side Effects and Benefits
Benefits:
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Treatment of Hypogonadism: Sustanon 250 is effective in treating symptoms of low testosterone, such as decreased libido, muscle mass decline, fatigue, and depressive moods.
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Muscle Growth and Strength: As a testosterone product, it has strong anabolic properties, which promote muscle growth and increased strength.
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Increased Red Blood Cell Production: It can stimulate the production of red blood cells, which can be beneficial for certain conditions like anemia.
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Increased Bone Density: It can help increase bone density and is sometimes used to treat osteoporosis caused by low androgen levels.
Side Effects:
Sustanon 250, like other testosterone products and anabolic steroids, can cause a range of side effects. These can vary depending on the dosage, duration of use, and individual sensitivity.
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Androgenic Side Effects: These are related to the male sex hormone effects of testosterone and can include:
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Acne and oily skin
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Male-pattern baldness (in genetically predisposed individuals)
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Increased body and facial hair growth
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Enlargement of the prostate gland (especially in older men)
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Estrogenic Side Effects: Testosterone can be converted into estrogen in the body through a process called aromatization. This can lead to:
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Gynecomastia (development of breast tissue in men)
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Fluid retention and high blood pressure
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Cardiovascular Side Effects:
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Changes in cholesterol levels (decreasing HDL "good" cholesterol and increasing LDL "bad" cholesterol)
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Increased risk of heart disease, heart attack, and stroke, especially with long-term abuse.
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Other Side Effects:
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Suppression of natural testosterone production and testicular atrophy (shrinking of the testes)
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Reduced sperm count and potential infertility
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Mood swings, irritability, and aggression
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Pain or swelling at the injection site
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Liver damage (less common with injectable testosterone compared to oral steroids)
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Sleep apnea may worsen.
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Pros and Cons
Pros:
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Sustained Release: The blend of esters provides a steady and prolonged release of testosterone, eliminating the need for frequent injections compared to single-ester testosterone products.
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Effective for HRT: It is a well-established and effective treatment for male hypogonadism.
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Anabolic Effects: It promotes muscle growth, strength gains, and increased red blood cell production.
Cons:
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Side Effects: The potential for a wide range of side effects, from mild to severe, is a significant drawback.
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Suppression of Natural Hormones: It suppresses the body's natural production of testosterone, which can lead to dependence and require a post-cycle therapy (PCT) to restore natural function after discontinuation.
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Detection Time: Its long-acting nature means it can be detected in drug tests for an extended period, making it a poor choice for competitive athletes.
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Abuse Potential: It is frequently misused in the athletic and bodybuilding communities, leading to significant health risks.
Dosage and Frequency
For medical use in treating male hypogonadism, a typical dosage is 1 ml (250 mg) every 3 weeks, administered via deep intramuscular injection. The exact dosage and frequency are determined by a healthcare professional based on the individual's condition and monitored through blood tests to maintain stable testosterone levels. Non-medical users, such as bodybuilders, often use higher doses and more frequent injections, which increases the risk of side effects.
Half-Life and Detection Time
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Half-Life: Sustanon 250's half-life is complex due to its four different esters. The half-lives range from approximately 2-3 days (for testosterone propionate) to about 15-18 days (for testosterone decanoate). The combined effect provides a sustained release over a period of about three to four weeks.
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Detection Time: Sustanon 250 has a very long detection time due to the long-acting testosterone decanoate ester. It can be detected in urine drug tests for up to 3 months or even longer, and in hair follicle tests for up to 12 months.
Steroidogenic, Progestogenic, and Prolactin Effects
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Steroidogenic: Sustanon 250 is a steroid. As a testosterone product, it is an androgenic and anabolic steroid (AAS), meaning it mimics the effects of testosterone. Its use will affect the body's natural steroidogenic pathways, primarily by suppressing the hypothalamic-pituitary-gonadal (HPG) axis, which is responsible for natural testosterone production.
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Progestogenic: Testosterone and its derivatives are not typically considered progestogenic. However, some anabolic steroids can have progestogenic activity, which can contribute to side effects like gynecomastia. While Sustanon 250 itself is not progestogenic, the estrogenic effects from its aromatization can be similar to some progestogenic effects, especially when it comes to water retention and gynecomastia.
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Prolactin: Testosterone use, especially in higher doses, can sometimes lead to an increase in prolactin levels. High prolactin levels can contribute to side effects like gynecomastia and erectile dysfunction.
Anabolic-Androgenic Ratio
The anabolic-androgenic ratio of testosterone is considered to be 100:100. This is the benchmark against which all other anabolic-androgenic steroids are measured. Since Sustanon 250 is a blend of different testosterone esters, its ratio is the same as that of pure testosterone. The anabolic effect refers to its ability to promote tissue growth (muscle, bone), while the androgenic effect refers to its ability to promote male secondary sex characteristics (e.g., body hair, deepened voice).
Pharmacological Properties
Half Life
10 days
Active Dose
72%
Detection
7.14 weeks
Concentration
250 mg/ml
Anabolic/Androgenic Profile
Usage Effectiveness
Activity Profile
Estrogenic
None
Progestanic
None
Water Retention
None
Aromatization
No
Benefits
Dosage Recommendations
Beginner
200-400 mg/week
Intermediate
400-600 mg/week
Advanced
600-800 mg/week
Evidence-based planning resources
Dive deeper into Sustanon 250 cycle design, stacking options, and harm-reduction checklists available inside Anabolic Planner.
- Sustanon 250 compound database overviewCompare Sustanon 250 with other steroid agents in the structured compound index.
- Sustanon 250 stack and cycle templatesReview evidence-based cycle outlines, dose progressions, and PCT pairings that incorporate Sustanon 250.
- Harm-reduction guide for Sustanon 250Refresh safety monitoring, lab work, and countermeasure strategies tailored for Sustanon 250 protocols.
Peer-reviewed reference material
Validate mechanisms, contraindications, and regulatory guidance for Sustanon 250 with trusted clinical databases.
- Sustanon 250 clinical research on PubMedSearch peer-reviewed human and veterinary studies discussing efficacy, endocrine impact, and contraindications.
- Sustanon 250 pharmacology via Drug Information PortalReview mechanisms, synonyms, regulatory status, and toxicology summaries from the U.S. National Library of Medicine.
Side Effects
Common
Rare
Severe
Safety Information
Liver Toxicity
None
Kidney Toxicity
Low
Cardiovascular Risk
Moderate
Disclaimer: This information is for educational purposes only. Always consult with a qualified healthcare professional before using any compounds.