Promagnon

What is Promagnon?

Promagnon, also known by its chemical name Chloromethylandrostenediol or 4-chloro-17α-methyl-androst-4-ene-3β,17β-diol, is a synthetic, orally active anabolic-androgenic steroid (AAS). It is a derivative of 4-androstenediol and a 17α-alkylated compound. It was briefly marketed as a "dietary supplement" and "prohormone" in the mid-2000s before being voluntarily discontinued.

Promagnon's chemical structure contains a chlorine group at the C4 position, which prevents it from being converted into estrogen (aromatization). This is a key feature that distinguishes it from other steroids. It is also closely related to other designer steroids, such as chlorodehydromethylandrostenediol (Halodrol-50) and chlorodehydromethyltestosterone (Oral Turinabol).

Side Effects and Benefits

Benefits:

• Anabolic Effects: As an anabolic-androgenic steroid, Promagnon is designed to promote muscle growth and protein synthesis.

• No Estrogenic Side Effects: The chlorine group at the C4 position prevents aromatization, meaning it does not convert to estrogen. This eliminates the risk of estrogenic side effects like gynecomastia (enlarged male breast tissue) and water retention.

Side Effects:

• Hepatotoxicity: Like other 17α-alkylated AAS, Promagnon can pose a risk of liver toxicity.

• Androgenic Side Effects: Despite having a relatively greater anabolic effect, it can still cause androgenic side effects. These can include:

  • Oily skin

  • Acne

  • Increased facial and body hair growth

  • Male pattern baldness (in predisposed individuals)

  • Virilization in women (development of male characteristics).

• Cardiovascular Issues: As with other AAS, there is a potential risk of adverse effects on the cardiovascular system, including changes in cholesterol levels (increasing LDL and decreasing HDL).

• Hormonal Disruption: Promagnon can suppress the body's natural hormone production, affecting the hypothalamic-pituitary-adrenal axis (HPAA). This can lead to hormonal disorders and infertility.

Pros and Cons

Pros:

• Strong Anabolic Activity: Promagnon is known for its muscle-building properties.

• No Aromatization: The lack of estrogen conversion is a significant advantage, as it avoids common side effects like gynecomastia and water retention.

Cons:

• Hepatotoxicity: The potential for liver damage is a major concern.

• Androgenic Effects: The risk of androgenic side effects remains.

• Legality: Promagnon is not a regulated medication and was sold as a "prohormone" or "dietary supplement," which raises concerns about its purity, legality, and safety.

• Hormonal Suppression: It can lead to the shutdown of natural testosterone production, requiring post-cycle therapy to restore hormonal balance.

Dosage and Frequency

Specific, medically approved dosages for Promagnon are not available as it was never a marketed pharmaceutical drug. Information on its usage comes from the context of its use as a designer steroid. Typical dosages for similar compounds are highly variable and dependent on the user's experience and goals, but are not medically recommended and can be dangerous.

Half-Life and Detection Time

Due to its status as a "designer" steroid, precise pharmacokinetic data for Promagnon is not publicly available. However, similar orally active 17α-alkylated steroids can have a half-life of several hours. The detection time in drug tests is typically much longer, as laboratories look for specific metabolites of the drug that can remain in the body for an extended period. For a similar compound, metabolites have been detected for up to 45 days after a single dose. The exact detection window for Promagnon would depend on the specific test and the user's metabolism.

Sterogenic, Progestogenic, and Prolactin Effects

• Estrogenic: Promagnon has no estrogenic effects because it cannot be aromatized due to its chemical structure.

• Progestogenic: There is no evidence in the provided information to suggest that Promagnon has significant progestogenic activity. Progestogens are a class of steroid hormones that bind to progesterone receptors and are involved in pregnancy and the menstrual cycle. While some anabolic steroids can have progestogenic activity, Promagnon is not listed as one of them.

• Prolactin: Anabolic-androgenic steroids can indirectly affect prolactin levels. High prolactin levels (hyperprolactinemia) are more commonly associated with progestogenic steroids, which can stimulate prolactin secretion. Elevated prolactin can lead to side effects like galactorrhea (milky discharge from nipples) and can inhibit the release of gonadotropin-releasing hormone (GnRH), leading to suppressed testosterone production and fertility issues. Given the lack of confirmed progestogenic activity for Promagnon, a direct prolactin effect is not expected, but it could be an indirect consequence of overall hormonal disruption.

Anabolic-Androgenic Ratio

The anabolic-androgenic ratio is a measure of a steroid's ability to promote muscle growth (anabolic) versus its ability to produce male characteristics (androgenic), relative to testosterone, which has a ratio of 1:1.

Based on the available information, Promagnon is described as having a "relatively greater anabolic than androgenic activity." While an exact numerical ratio is not provided for Promagnon itself, this indicates that its anabolic ratio would be higher than 1. For similar compounds like nandrolone and stanozolol, the anabolic-androgenic ratios are reported as 10:1 and 30:1, respectively. Therefore, one could infer that Promagnon's ratio would likely be greater than 1:1.