Primobolan Depot (Methenolone Enanthate)
Active Substance: Primobolan Depot
Description
What is Primobolan Depot (Methenolone Enanthate)?
Primobolan Depot (Methenolone Enanthate) is a long-acting injectable anabolic-androgenic steroid (AAS). It is also known by other names, including:
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Methenolone Enanthate
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Metenolone Enanthate
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Nibal Injection
It is a synthetic derivative of dihydrotestosterone (DHT). Historically, it has been used medically to treat conditions like anemia due to bone marrow failure. In the modern era, its medical use has been largely discontinued, and it is primarily found on the black market for performance-enhancing and physique-enhancing purposes.
Side Effects and Benefits
Benefits:
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Anabolic Effects: It has moderate anabolic effects, meaning it can help with muscle growth and protein synthesis.
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Weak Androgenic Effects: Compared to many other steroids, it has weaker androgenic effects. This means it is less likely to cause side effects like severe acne, body hair growth, and male pattern baldness (though these can still occur, especially in individuals predisposed to them).
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No Estrogenic Effects: Primobolan is a DHT derivative and does not aromatize (convert to estrogen). This means it does not cause estrogenic side effects like gynecomastia (enlargement of male breast tissue) or water retention.
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No Liver Toxicity: Unlike oral steroids, the injectable form of Primobolan does not have a risk of liver damage.
Side Effects:
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Virilization in Women: As an androgen, it can cause masculinizing effects in women, including a deepened voice, increased body and facial hair, and clitoral enlargement.
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Suppression of Natural Testosterone Production: Like all anabolic steroids, it can suppress the body's natural production of testosterone, which can lead to issues such as reduced libido and fatigue. Post-cycle therapy (PCT) is often used to help restore hormone levels.
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Cardiovascular Issues: It can negatively affect cholesterol levels, specifically by increasing LDL (bad cholesterol) and decreasing HDL (good cholesterol), which can increase the risk of cardiovascular disease.
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Hair Loss: In genetically predisposed individuals, its androgenic properties can accelerate male pattern baldness.
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Psychological Effects: Some users may experience mood swings, irritability, or increased aggression.
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Acne and Oily Skin: Increased sebaceous gland activity can lead to oily skin and acne.
Pros and Cons
Pros:
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Relatively mild in terms of androgenic and estrogenic side effects.
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Does not cause water retention or gynecomastia.
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Not liver toxic in its injectable form.
Cons:
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Weak anabolic effects compared to more potent steroids.
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Can still cause androgenic side effects.
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Suppresses natural testosterone production.
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Can negatively impact cardiovascular health.
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Illegal and dangerous to obtain without a medical prescription.
Dosage and Frequency
Dosages for performance enhancement can vary widely, but common ranges often cited on illicit sources are:
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Men: 200-400 mg per week.
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Women: 50-100 mg per week.
The frequency of injection is typically once or twice per week due to its long half-life.
Half-Life and Detection Time
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Half-Life: The elimination half-life of Methenolone Enanthate is reported to be approximately 10.5 days.
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Detection Time: Due to its long-acting nature and metabolites, it has a long detection window in drug tests. Detection times can vary significantly depending on the testing method, individual metabolism, and other factors, but it can be detected for 4-5 weeks or even longer.
Sterogenic, Progestogenic, and Prolactin Effects
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Estrogenic: Primobolan has no estrogenic effects. It does not aromatize.
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Progestogenic: It is not a progestin and does not have any significant progestogenic activity.
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Prolactin: It does not cause a rise in prolactin levels.
Anabolic-Androgenic Ratio
The anabolic-androgenic ratio of Methenolone Enanthate is approximately 88:44. This means it is considered to be a moderately anabolic and weakly androgenic compound. The ratio is often presented as a comparison to testosterone, which has a ratio of 100:100.
Pharmacological Properties
Half Life
5 days
Active Dose
70%
Detection
3.57 weeks
Concentration
250 mg/ml
Anabolic/Androgenic Profile
Usage Effectiveness
Activity Profile
Estrogenic
None
Progestanic
None
Water Retention
None
Aromatization
No
Benefits
Dosage Recommendations
Beginner
200-400 mg/week
Intermediate
400-600 mg/week
Advanced
600-800 mg/week
Evidence-based planning resources
Dive deeper into Primobolan Depot (Methenolone Enanthate) cycle design, stacking options, and harm-reduction checklists available inside Anabolic Planner.
- Primobolan Depot (Methenolone Enanthate) compound database overviewCompare Primobolan Depot (Methenolone Enanthate) with other steroid agents in the structured compound index.
- Primobolan Depot (Methenolone Enanthate) stack and cycle templatesReview evidence-based cycle outlines, dose progressions, and PCT pairings that incorporate Primobolan Depot (Methenolone Enanthate).
- Harm-reduction guide for Primobolan Depot (Methenolone Enanthate)Refresh safety monitoring, lab work, and countermeasure strategies tailored for Primobolan Depot (Methenolone Enanthate) protocols.
Peer-reviewed reference material
Validate mechanisms, contraindications, and regulatory guidance for Primobolan Depot (Methenolone Enanthate) with trusted clinical databases.
- Primobolan Depot clinical research on PubMedSearch peer-reviewed human and veterinary studies discussing efficacy, endocrine impact, and contraindications.
- Primobolan Depot pharmacology via Drug Information PortalReview mechanisms, synonyms, regulatory status, and toxicology summaries from the U.S. National Library of Medicine.
Side Effects
Common
Rare
Severe
Safety Information
Liver Toxicity
None
Kidney Toxicity
Low
Cardiovascular Risk
Moderate
Disclaimer: This information is for educational purposes only. Always consult with a qualified healthcare professional before using any compounds.