Methyldienolone

Methyldienolone, also known as Methyl-D or RU-3467, is a synthetic, orally active anabolic-androgenic steroid (AAS) and a derivative of 19-nortestosterone. It's a banned substance on the World Anti-Doping Agency's (WADA) prohibited list.

Side Effects

Methyldienolone is an extremely potent and harsh compound, and its use is associated with significant health risks. Side effects can be severe and include:

• Hepatotoxicity: Like other 17α-alkylated oral steroids, methyldienolone is highly liver-toxic and can cause liver damage.

• Cardiovascular Issues: Use can increase the risk of blood clots, leading to a heart attack, stroke, or deep vein thrombosis (DVT). It can also negatively affect cholesterol levels, increasing LDL (bad) cholesterol and decreasing HDL (good) cholesterol.

• Hormonal Suppression: It severely suppresses natural testosterone production and can lead to a decreased sperm count.

• Estrogenic and Progestogenic effects: Although it does not aromatize into estrogen, its progestogenic activity can lead to estrogen-like side effects such as gynecomastia (enlarged breast tissue in men) due to the upregulation of prolactin.

• Androgenic effects: Side effects related to its androgenic nature include acne, accelerated hair loss in those predisposed to male pattern baldness, and virilization in women (deepening of the voice, clitoral enlargement, and unwanted hair growth).

• Psychological effects: It may cause mood swings, increased aggression, and depression.

Benefits

The primary benefit of Methyldienolone is its potent anabolic effect, which promotes muscle growth and strength gains. Its high anabolic-to-androgenic ratio makes it appealing for those seeking to build muscle with less of the overt androgenic side effects of other steroids, but this is often a misconception, as the androgenic side effects are still very present.

Pros and Cons

Pros:

• Significant Muscle and Strength Gains: It is a very powerful anabolic agent.

Cons:

• High Toxicity: It poses a high risk of liver damage.

• Severe Side Effects: It can lead to serious cardiovascular and hormonal issues, and its progestogenic activity can cause gynecomastia.

• Illegal and Banned: It is not approved for medical use and is banned by all major sports organizations.

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Dosage and Half-Life

There is no established or medically recommended dosage for Methyldienolone, as it was never approved for medical use. The half-life and detection time are also not well-documented, but as an oral anabolic steroid, it likely has a short half-life of a few hours to a day, similar to other 17α-alkylated steroids. However, its metabolites may be detectable in urine for weeks or even months after use.

Sterogenic, Progestogenic, and Prolactin Effects

Methyldienolone is a progestogenic steroid. This means it can bind to and activate the progesterone receptor in the body. This progestogenic activity is significant because it can lead to side effects like gynecomastia, particularly when used with other aromatizing steroids. The progestogenic nature of the compound stimulates prolactin release, which is a hormone that can cause breast tissue growth.

Anabolic Androgenic Ratio

The anabolic-to-androgenic ratio of Methyldienolone is approximately 10:1. This is in comparison to testosterone, which has a ratio of 1:1. The ratio indicates that it is a highly anabolic compound.