Diandrol
Active Substance: Diandrol
Description
Diandrol (Methandrostenolone / Metandienone)
What is it? Diandrol is a trade name for the anabolic steroid methandrostenolone, also commonly known as Dianabol or Dbol. It is a synthetic derivative of testosterone that was developed in the 1950s. It is one of the most well-known and widely used oral anabolic steroids, particularly in the fields of bodybuilding and performance enhancement. Methandrostenolone works by binding to androgen receptors in the body, which leads to increased protein synthesis, enhanced nitrogen retention, and improved glycogenolysis. These effects contribute to significant muscle growth and increased strength.
Benefits and Side Effects
Benefits:
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Rapid Muscle Growth: Dianabol is highly effective for promoting quick and substantial increases in muscle mass, particularly when combined with resistance training.
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Increased Strength: Users often experience a significant boost in muscular strength, allowing for heavier and more intense workouts.
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Enhanced Recovery: By increasing protein synthesis and nitrogen retention, it can accelerate muscle recovery after strenuous exercise.
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Improved Endurance: The increase in glycogenolysis can lead to greater energy availability during physical activity, potentially improving endurance.
Side Effects:
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Hepatotoxicity (Liver Damage): As an oral steroid, Dianabol is 17-alpha-alkylated, which makes it highly toxic to the liver. Prolonged use or high doses can cause severe liver damage, including benign and malignant tumors, and liver failure.
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Cardiovascular Issues: It can negatively impact cholesterol levels, increasing "bad" low-density lipoprotein (LDL) and decreasing "good" high-density lipoprotein (HDL). This raises the risk of heart attack and stroke. It can also lead to high blood pressure.
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Hormonal Imbalances:
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Estrogenic Side Effects: Methandrostenolone has moderate estrogenic activity because it can be converted into methylestradiol (a type of estrogen) via the aromatase enzyme. This can lead to side effects such as gynecomastia (male breast tissue growth) and water retention.
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Androgenic Side Effects: Despite having a lower androgenic ratio than testosterone, it can still cause virilization (development of male characteristics) in women, including a deepened voice, increased facial and body hair, and clitoral enlargement. In men, it can cause acne, male-pattern baldness, and suppression of natural testosterone production, leading to testicular atrophy (shrinking of the testicles) and low sperm count.
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Pros and Cons
Pros:
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Effective for rapid muscle and strength gains.
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Oral administration is convenient for some users.
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Historically, it was one of the first and most accessible steroids.
Cons:
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High risk of severe liver damage.
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Significant cardiovascular risks.
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Numerous and potentially irreversible side effects related to hormonal imbalances.
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Suppresses the body's natural hormone production.
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Most of the weight gained is often water retention, which is lost after discontinuing use.
Dosage and Frequency
There are no medically approved dosages for Diandrol for performance enhancement. In historical medical contexts, doses for conditions like osteoporosis or muscle wasting were typically low (e.g., 2.5-20 mg per day). However, for performance-enhancing purposes, non-medical users have been known to take much higher doses, often in a range of 15-50 mg per day. The frequency is usually divided throughout the day due to its short half-life.
Half-Life and Detection Time
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Half-Life: The half-life of methandrostenolone is relatively short, approximately 3 to 6 hours. This is why users often take multiple doses throughout the day to maintain stable blood levels.
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Detection Time: Due to its metabolism, methandrostenolone can be detected in urine for an extended period, typically around 5 to 6 weeks after the last use. This can vary depending on individual metabolism, dosage, and duration of use.
Sterogenic, Progestogenic, and Prolactin Effects
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Sterogenic Effects: Diandrol is a potent anabolic-androgenic steroid. Its primary mechanism of action is its strong binding to the androgen receptor, which promotes anabolism (muscle building) and moderate androgenic effects (development of male characteristics).
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Progestogenic Effects: Methandrostenolone has no progestogenic activity.
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Prolactin Effects: Methandrostenolone does not directly increase prolactin levels. However, elevated estrogen levels resulting from the aromatization of Diandrol can indirectly lead to an increase in prolactin. High prolactin levels can contribute to side effects like gynecomastia and erectile dysfunction.
Anabolic-Androgenic Ratio
The anabolic-androgenic ratio of methandrostenolone is typically cited as being between 1:1 and 1:8, with most sources suggesting it is more anabolic than androgenic. For comparison, testosterone has a ratio of 1:1. It's important to note that these ratios are often based on animal studies and can vary in human response.
Pharmacological Properties
Half Life
4.3 hours
Active Dose
100%
Detection
0.89 days
Concentration
10 mg/tab
Anabolic/Androgenic Profile
Usage Effectiveness
Activity Profile
Estrogenic
None
Progestanic
None
Water Retention
None
Aromatization
No
Benefits
Dosage Recommendations
Beginner
20-40 mg/week
Intermediate
40-60 mg/week
Advanced
60-100 mg/week
Evidence-based planning resources
Dive deeper into Diandrol cycle design, stacking options, and harm-reduction checklists available inside Anabolic Planner.
- Diandrol compound database overviewCompare Diandrol with other steroid agents in the structured compound index.
- Diandrol stack and cycle templatesReview evidence-based cycle outlines, dose progressions, and PCT pairings that incorporate Diandrol.
- Harm-reduction guide for DiandrolRefresh safety monitoring, lab work, and countermeasure strategies tailored for Diandrol protocols.
Peer-reviewed reference material
Validate mechanisms, contraindications, and regulatory guidance for Diandrol with trusted clinical databases.
- Diandrol clinical research on PubMedSearch peer-reviewed human and veterinary studies discussing efficacy, endocrine impact, and contraindications.
- Diandrol pharmacology via Drug Information PortalReview mechanisms, synonyms, regulatory status, and toxicology summaries from the U.S. National Library of Medicine.
Side Effects
Common
Rare
Severe
Safety Information
Liver Toxicity
Moderate
Kidney Toxicity
Low
Cardiovascular Risk
Moderate
Disclaimer: This information is for educational purposes only. Always consult with a qualified healthcare professional before using any compounds.