Bromantane

What is Bromantane?

Bromantane, also known by its brand name Ladasten, is an atypical central nervous system stimulant and anxiolytic drug developed in Russia. It belongs to the adamantane family of drugs, which also includes amantadine and memantine. Bromantane is classified as an "actoprotector," a term for a substance that enhances an organism's physical and mental performance under extreme conditions without increasing oxygen consumption or heat production. In Russia, it is approved for the treatment of neurasthenia, a condition characterized by physical and mental fatigue.

Benefits and Side Effects

Benefits:

• CNS Stimulant and Anxiolytic Effects: It is known to have a unique combination of stimulating and anxiety-reducing properties. This can lead to improved mental performance, focus, and motivation while also reducing feelings of stress and anxiety.

• Enhanced Physical Performance: Bromantane has been shown to improve physical endurance and muscle strength, which is why it has been used as a performance-enhancing drug.

• Neuroprotective Properties: Like other adamantane derivatives, it may have neuroprotective effects, which could be beneficial for conditions like Alzheimer's and Parkinson's diseases.

• No Observed Addiction or Withdrawal: Studies have not found signs of dependence or withdrawal symptoms associated with its use.

• Low Peripheral Sympathomimetic Effects: Unlike many conventional stimulants, it has a low impact on the peripheral nervous system, meaning it is less likely to cause side effects like increased heart rate or blood pressure.

Side Effects:

• Hypothermia/Hyperthermia: In animal studies, prolonged use of high doses has shown initial hypothermia, which later transitioned to slight hyperthermia.

• Cholinergic Toxicity: Higher doses may cause cholinergic toxicity.

• Gastrointestinal issues: High doses in animal studies have been associated with regurgitation, diarrhea, and polyuria (excessive urination).

• Reduced Motor Activity: In male rats, high doses were shown to reduce motor activity.

Pros and Cons

Pros:

• Dual Action: Offers both psychostimulant and anxiolytic effects.

• Long-lasting Effect: The stimulatory action builds gradually and can last for 8-12 hours.

• Lack of Addiction Potential: Studies have not found it to be associated with addiction or withdrawal.

• Improved Cognitive and Physical Performance: Can enhance both mental and physical capabilities.

Cons:

• Limited Research: Most of the research on Bromantane is from Russia, and there is a lack of widespread, independent clinical trials in other countries.

• Doping Control: It is on the World Anti-Doping Agency (WADA) prohibited list, making it a concern for athletes.

• Uncertain Long-Term Effects: Due to limited research, the long-term effects of using Bromantane are not well understood.

• Dosage Variability: Dosages mentioned in research are often for animal studies and may not directly translate to safe or effective human doses.

Dosage and Frequency

There is no widely accepted or medically approved dosage for Bromantane outside of its use in Russia for neurasthenia. However, clinical trials in Russia for asthenia have used daily doses of 50 mg or 100 mg for 28 days. In animal studies, a wide range of doses has been tested, showing different effects at various levels.

Half-Life and Detection Time

• Half-life: The elimination half-life of Bromantane in humans is approximately 11.21 hours.

• Detection Time: While a specific detection window is not universally established, its primary metabolite, 6β-hydroxybromantane, has been detectable in urine for up to 30 hours after a single dose. Due to its status as a prohibited substance in sports, sophisticated testing methods exist for its detection.

Sterogenic, Progestogenic, and Prolactin Effects

Information on Bromantane's direct effects on sterogenic, progestogenic, and prolactin levels is not readily available in the provided search results. However, some studies on similar drugs, like bromocriptine, which also affect prolactin, have shown interactions with estrogen receptors but not with progesterone or testosterone receptors. It is not an anabolic-androgenic steroid, and as such, it would not have an anabolic-androgenic ratio.

Anabolic Androgenic Ratio

Bromantane is not an anabolic-androgenic steroid (AAS), and therefore, it does not have an anabolic-androgenic ratio. This ratio is a measure used to compare the anabolic (muscle-building) effects of a steroid to its androgenic (masculinizing) effects. Since Bromantane is not a steroid, this ratio does not apply to it.