Trestolone Acetate (MENT)

Trestolone Acetate, also known by the developmental code name MENT acetate or simply MENT, is a synthetic anabolic-androgenic steroid (AAS) and progestogen.

Here is a detailed breakdown based on medical research:

Trestolone Acetate (MENT)

• Different Names/Chemical Names:

  • MENT (7$\alpha$-methyl-19-nortestosterone) - This is the parent steroid.

  • MENT acetate (7$\alpha$-methyl-19-nortestosterone 17$\beta$-acetate) - This is the ester form, which is used for injection or implant.

  • Orgasteron acetate (developmental code name).

  • 7$\alpha$-Methylnandrolone (as it is a derivative of nandrolone, which is 19-nortestosterone).

• Detailed Explanation: Trestolone Acetate is the acetate ester of the steroid Trestolone. It is a powerful synthetic steroid and a derivative of nandrolone (19-nortestosterone), modified with a methyl group at the C7α position. It was primarily developed as a potential candidate for a male hormonal contraceptive due to its potent ability to suppress the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which leads to temporary infertility. It has also been investigated for use in androgen replacement therapy (ART). The drug is classified as an androgen, anabolic steroid, and progestogen. It has never been approved or marketed for medical use.

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Side Effects and Benefits

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Pros and Cons

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Dosage and Frequency

Note: As an unapproved, investigational drug, there are no standardized clinical dosages for performance enhancement. Information on non-medical use is anecdotal and highly variable.

• Clinical Research (Implant): Studies for male contraception used subcutaneous implants that released approximately 0.3 to 1.2 mg of MENT per day.

• Non-Medical Use (Injection): Due to its very short half-life as the acetate ester, it is often injected daily at varying doses (e.g., 10-50 mg per day or higher).

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Half-Life and Detection Time

• Half-Life (Trestolone - the active drug):

  • Trestolone (the active drug, MENT) itself has an extremely short terminal half-life of about 40 minutes when administered intravenously.

  • Trestolone Acetate is an ester, which serves as a pro-drug. It is rapidly converted to the active Trestolone upon injection. The half-life of the ester dictates the release schedule, and the acetate ester is considered very short, requiring daily or every-other-day injections.

  • Trestolone Enanthate (a longer ester form) would have a longer half-life, more like other enanthate esters (days, not minutes), but this is a different compound.

• Detection Time (Non-Specific):

  • Specific detection times for Trestolone Acetate in sports drug testing are not widely published/standardized for this unapproved compound, but like most short-ester injectable AAS, it could potentially be detectable for days to a few weeks (typically 3-6 weeks) depending on the dose, frequency, and sensitivity of the drug test. However, the presence of its metabolites in urine can be detectable for longer periods.

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Sterogenic, Progestronic, and Prolactin Effects

• Sterogenic (Estrogenic): Trestolone is an aromatizable steroid, meaning it converts to an estrogen—specifically, 7$\alpha$-methylestradiol. This estrogen is potent, and elevated levels can lead to typical estrogenic side effects like water retention and gynecomastia.

• Progestronic: Trestolone is a potent progestogen (a progestin). It acts as an agonist of the progesterone receptor (PR). This activity contributes to its strong HPTA suppression and can increase the risk of progestin-related side effects, particularly gynecomastia.

• Prolactin Affects: While the research is complex, potent progestogens often have an indirect relationship with prolactin. The strong estrogenic nature of MENT can also lead to increased prolactin secretion. Elevated prolactin, coupled with high estrogen/progestogenic activity, is a potential mechanism for AAS-induced gynecomastia and can cause symptoms like reduced libido.

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Anabolic to Androgenic Ratio

Trestolone is known for having a very favorable, high anabolic to androgenic ratio.

• Anabolic:Androgenic Ratio (Approximate): 2300:100 (or 23:1)

(Note: These ratio figures are derived from early testing using classic animal bioassays, comparing the compound to testosterone, which is set as 100:100. They represent an extremely high anabolic rating relative to its androgenic activity.)