Nilevar

Nilevar, also known by its generic name norethandrolone, is an androgen and anabolic steroid (AAS). It was one of the first anabolic steroids to be marketed with a favorable separation of anabolic (muscle-building) and androgenic (masculinizing) effects. It was initially introduced in the United States in the late 1950s but was mostly discontinued in the 1980s due to concerns about liver damage. It may still be available for use in some countries, such as France.

Benefits and Pros

• Muscle Growth: Nilevar was developed to promote muscle growth and increase strength.

• Medical Use: It was used to treat conditions involving muscle wasting, severe burns, physical trauma, and aplastic anemia. It can also help with weight gain in people who have lost too much weight due to illness or injury.

• Anabolic Effects: It has strong anabolic effects relative to its androgenic effects, making it a "favorable" steroid in terms of its intended purpose of building tissue.

Side Effects and Cons

• Hepatotoxicity: One of the most significant risks associated with Nilevar is liver damage. As a 17-alpha-alkylated oral steroid, it poses a risk of hepatotoxicity, which can lead to elevated liver enzymes, liver damage, and in rare cases, liver tumors or liver failure.

• Masculinization (Virilization): Side effects in women and children can include acne, increased hair growth (hirsutism), voice changes (deepening), and clitoral enlargement. These effects can be irreversible.

• Estrogenic Effects: Nilevar can be converted into the potent estrogen, ethylestradiol. This can lead to estrogenic side effects such as fluid retention and gynecomastia (breast enlargement in men).

• Cardiovascular Risks: Like other AAS, it can negatively affect cholesterol levels by raising LDL ("bad" cholesterol) and lowering HDL ("good" cholesterol), which increases the risk of heart disease.

• Hormonal Imbalances: It can suppress the body's natural production of hormones. In men, this can lead to testicular shrinkage, reduced sperm production, and infertility.

• Psychological Effects: Mood changes, including aggression ("roid rage"), irritability, and depression, have been reported with anabolic steroid use.

Dosage and Frequency

Information on the specific dosages and frequency for Nilevar (norethandrolone) is limited due to its discontinued status. However, for similar anabolic steroids, dosages and frequency can vary widely depending on the specific medical condition being treated and are always determined by a healthcare professional. Non-medical use and dosages can be highly variable and are not officially recognized.

Half-Life and Detection Time

• Half-Life: The half-life of Nilevar (norethandrolone) is not widely available, but the half-lives of anabolic steroids vary significantly. For example, some oral steroids have a half-life of a few hours, while others, and injectable forms, can have half-lives of several days.

• Detection Time: The detection time for anabolic steroids varies based on the specific drug, dosage, and method of administration (oral vs. injectable), as well as individual metabolism. Oral anabolic steroids can be detectable in urine for several weeks, while some injectable forms can be detected for several months. Hair follicle testing can detect steroids for up to a year or more.

Sterogenic, Progestronic, and Prolactin Effects

• Sterogenic: Nilevar is a synthetic steroid. It is a derivative of 19-nortestosterone (nandrolone), which is itself a synthetic form of testosterone.

• Progestronic: Nilevar has strong progestogenic activity, meaning it can act on progesterone receptors in the body. The progestogenic potency is similar to that of norethisterone. This activity can influence hormonal balance and may contribute to certain side effects.

• Prolactin: Anabolic steroids, particularly those with progestogenic activity like Nilevar, can increase prolactin levels. Elevated prolactin can cause side effects such as gynecomastia (breast development in men) and galactorrhea (lactation) in both men and women.

Anabolic Androgenic Ratio

Nilevar (norethandrolone) has a high ratio of anabolic to androgenic activity. When it was first developed, it was found to have a high anabolic-to-androgenic ratio (AAR) of approximately 10:1 when compared to testosterone, which has a ratio of 1:1. This favorable ratio was a key reason for its initial marketing as an "anabolic" steroid with reduced masculinizing effects.