Neotest 250

What is Neotest 250 / alternate names / chemical identity

• Neotest 250 is (or was) a brand name for testosterone decanoate, an injectable testosterone ester. 

• It was marketed (in veterinary / underground contexts) by Loeffler (Mexico) as a single-ester testosterone decanoate formulation. 

• In medical / pharmaceutical use, testosterone decanoate is rarely used as a standalone; it more commonly appears as one ester in multi-ester testosterone blends (e.g. in Sustanon, Omnadren)

• Chemical formula / identity: testosterone decanoate is an androgen/anabolic steroid where the decanoate ester is attached at the 17β-hydroxyl group, prolonging its release after injection. 

So “Neotest 250” is essentially testosterone decanoate, 250 mg (in its brand/underground form).

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Mechanism & expected effects (benefits)

As with any exogenous testosterone / anabolic steroid, the effects stem from:

1. Androgen receptor activation → promoting anabolic (muscle-building) and androgenic (masculinizing) effects.

2. Positive nitrogen balance / enhanced protein synthesis — more efficient use of amino acids in muscle tissue. 

3. Increased red blood cell production / hematocrit (via erythropoiesis stimulation), which can improve oxygen delivery.

4. Suppression of glucocorticoid effects / anti-catabolic properties — testosterone tends to oppose the catabolic actions of cortisol. Improved recovery, strength gains, lean mass accumulation — when combined with resistance training, proper diet. Many users of anabolic steroids report these gains. 

So the “benefits” (in the context of performance / physique use) are typical of exogenous testosterone / AAS: increased muscle size, strength, improved recovery, better nitrogen retention, etc.

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Side effects, risks, and downsides

Because Neotest 250 is just a form of testosterone, its side effect profile is largely that of testosterone / anabolic steroids. Some issues are better documented than others. Key risks include:

Androgenic / virilization side effects

• Acne, oily skin

• Increased body hair / facial hair

• Male pattern baldness (if genetically predisposed) via conversion to DHT (via 5α-reductase) 

• Enlargement of prostate, acceleration of benign prostatic hyperplasia (BPH) in susceptible men

• Potential virilization in female users (voice deepening, clitoral enlargement, hirsutism) if misused

Estrogenic / aromatization side effects

Testosterone (including decanoate forms) aromatizes (converts) to estrogen, so risks include:

• Gynecomastia (male breast enlargement)

• Water retention, edema

• Increased blood pressure from fluid retention

• Possibly negative effects on lipid profile (lower HDL, higher LDL) 

Suppression of endogenous testosterone production

When exogenous testosterone is used, the hypothalamic–pituitary–gonadal (HPG) axis is suppressed. That means:

• Reduced LH / FSH → testicular atrophy

• After stopping, there can be a period of low natural testosterone (hypogonadism)

• Recovery may require post-cycle therapy (PCT) in bodybuilding settings

Cardiovascular risks

• Adverse changes in lipid profiles (decreased HDL, increased LDL) 

• Possible increase in hematocrit / blood viscosity, raising risk of thrombosis, hypertension

• Potential negative effects on cardiovascular structure/function in long-term use

Other risks

• Possible negative effects on liver (though injectable testosterone esters are less hepatotoxic than oral 17α-alkylated steroids) 

• Possible negative psychiatric effects (mood swings, aggression, irritability, depression on withdrawal)

• Sleep apnea, fluid retention

• Adverse effects on cholesterol, blood lipids, possibly increased cardiovascular disease risk

Progestogenic / prolactin / estrogen interactions

Although testosterone itself is not strongly progestogenic, some of its downstream effects and interactions can influence prolactin or progestin-like pathways in some contexts. However, the direct “sterogenic progestrogenic prolactin” effects are more relevant for certain synthetic steroids (especially “19-nor” derivatives) than for pure testosterone.

In the case of testosterone decanoate / Neotest 250:

• It is not known to have strong progestogenic activity.

• It may slightly raise prolactin in some individuals indirectly (via estrogenic feedback, or via interactions in the pituitary), but this is not regarded as a primary effect.

• If someone were stacking with compounds that have progestogenic or dopamine antagonism (e.g. trenbolone, some progestins, or particular synthetic steroids), then prolactin elevation becomes more of a concern.

So while “progestogenic / prolactin effects” are a concern in certain anabolic steroids, for pure testosterone decanoate they are minor or limited in most users, but not zero in sensitive individuals.

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Pharmacokinetics: half-life, detection time, dosing & frequency

Half-life and detection

• Some sources report a half-life for testosterone decanoate of 15 days for “active life” (i.e. how long its effect persists) in the body. 

• Others suggest a half-life around 7–10 days for the decanoate ester in practical use. 

• Because it is a long-acting ester, its physiological (or pharmacological) effects last considerably longer than shorter esters. 

• Detection time (i.e. how long it can be found in urine / doping tests) is reported (in underground / steroid literature) to be as long as ~3 months (≈ 90 days) in some cases. 

• However, detection windows depend heavily on dose, metabolism, test sensitivity, individual liver / kidney function, etc.

Thus, while the “half-life” is on the order of 1 to 2 weeks, the residual detectability can last multiple weeks to months.

Dosing & frequency (from anecdotal / bodybuilding sources)

• Because Neotest 250 (testosterone decanoate) was used in veterinary / underground contexts, there is no standard medical dosing for human performance use.

• Some bodybuilding/underground sources claim that 500 mg per week is a common “effective” dose for performance enhancement.

• Some propose 250 mg every 7–10 days (i.e. approximately 2.5 to 3.5 injections per month) for maintenance use in milder cycles.

• More aggressive users sometimes report use of 750–1000 mg per week — but such doses carry greatly elevated risks. 

• Because of its long release profile, doses might be spaced further apart than with shorter esters; but spacing too far can lead to hormonal troughs.

In practice, users might inject weekly or every 7–10 days regardless, to maintain more stable blood levels.

I must emphasize: these are non-medical, anecdotal regimens, not approved therapeutic protocols.

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Anabolic:Androgenic ratio (numeric estimate)

In many steroid reference systems, testosterone is used as the baseline “100 / 100” (i.e. anabolic = 100, androgenic = 100). Many derived or synthetic steroids are compared to that benchmark.

• According to steroid/underground sources, Neotest 250 / testosterone decanoate also is given an androgenic:anabolic rating of 100 / 100 (i.e. “baseline”) in many steroid user compendia.

• In other words, as it is essentially testosterone with a long ester, its anabolic:androgenic ratio is about 1:1 in these rating systems.

This means it is as androgenic (masculinizing) as it is anabolic (muscle-building) in the standard comparative metric.

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Pros & cons (summary)

Here’s a comparison of likely advantages vs disadvantages (with the caveat that this is speculative / based on non-clinical sources):

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Caveats, uncertainties, and health warnings

• Much of the information on Neotest 250 comes from underground / bodybuilding / steroid enthusiast sources, not from rigorous clinical trials.

• The original Neotest 250 (veterinary product) is reportedly no longer manufactured; what is found today under that name may be counterfeit or re-branded testosterone decanoate. 

• Individual variation (genetics, liver/kidney function, enzyme polymorphisms) affects side effect susceptibility, metabolism, detection, etc.

• Use of anabolic steroids without medical indication is illegal in many jurisdictions and has serious health risks.

• Any regimen that suppresses endogenous testosterone should have appropriate monitoring (hormones, lipids, CBC, liver enzymes, cardiovascular markers) and a plan for recovery / post-cycle therapy.