Mibolerone

Mibolerone is a potent, orally active synthetic anabolic-androgenic steroid (AAS). It's a derivative of nandrolone (19-nortestosterone) and was originally developed by the Upjohn company as a veterinary drug, specifically for preventing estrus (heat) in female dogs. Due to its extreme potency, it is not used in humans for medical purposes.

Other Names

Mibolerone is also known by several other names, including:

• Dimethylnortestosterone (DMNT)

• U-10997

• CDB-904

• Cheque Drops (a former brand name)

• Matenon (a former brand name)

Side Effects and Benefits

Benefits (in a veterinary context, as a drug for dogs):

• Prevention of estrus: Its primary intended use was to effectively prevent a female dog from coming into heat, which was a practical benefit for breeders and pet owners.

Side Effects (in both animals and humans):

• Extreme Hepatotoxicity: Mibolerone is a 17$\alpha$-alkylated steroid, meaning it has a modified carbon structure that allows it to survive the first pass through the liver. This modification, however, makes it highly toxic to the liver.

• Androgenic side effects: Due to its powerful androgenic nature, it can cause severe masculinizing effects, including:

  • Virilization (development of male characteristics in females)

  • Hirsutism (excessive hair growth)

  • Clitoral enlargement

  • Deepening of the voice

  • Aggression and mood swings

• Cardiovascular strain: Like other anabolic steroids, it can negatively impact cholesterol levels, increasing LDL ("bad") cholesterol and decreasing HDL ("good") cholesterol, which raises the risk of cardiovascular disease.

• Gynecomastia: While highly androgenic, its progestogenic activity can lead to gynecomastia (enlargement of male breast tissue).

• Suppression of natural hormone production: It heavily suppresses the body's natural production of testosterone, which can lead to testicular atrophy and infertility.

• Masculinization of female offspring: In the veterinary studies on pregnant dogs, mibolerone was shown to cause masculinization in female pups.

Pros and Cons

Pros:

• Extreme potency: Mibolerone is considered one of the most potent anabolic steroids available, producing rapid and significant increases in strength and aggression.

• Oral administration: Its oral form (drops) makes it easy to administer.

Cons:

• Severe side effects: The cons far outweigh the pros for human use. The extreme liver toxicity and powerful androgenic effects make it highly dangerous.

• Limited utility: Its effects are so rapid and short-lived that it's generally only used by athletes for a brief period before a competition to increase aggression and strength, but this comes at a high cost to health.

Dosage and Frequency

There is no medically recommended dosage for human use. Information on this is only found in the context of performance-enhancing drug use, and dosages are not standardized or safe. Due to its high potency and toxicity, even small doses are considered dangerous.

Half-Life and Detection Time

• Half-life: The half-life of mibolerone is not well-documented for human use, but it is known to be very short. One study on a single dose showed that the parent compound was essentially undetectable after 24 hours. The main metabolite was detectable for up to five days.

• Detection time: Due to the rapid metabolism of the parent drug, a drug test for mibolerone would primarily look for its metabolites. While the parent compound is gone quickly, its metabolites may be detectable for a few days up to a week. However, new detection methods can extend this window significantly.

Steroidogenic, Progestogenic, and Prolactin Effects

• Steroidogenic: Mibolerone is a synthetic steroid with powerful anabolic and androgenic properties.

• Progestogenic: Mibolerone is a derivative of nandrolone, which is known for its progestogenic activity. Mibolerone has significant progestogenic activity, meaning it can bind to the progesterone receptor. This can contribute to side effects like gynecomastia and the suppression of natural hormone production.

• Prolactin: Due to its progestogenic nature, mibolerone can increase prolactin levels, which can also contribute to gynecomastia and, in some cases, other side effects associated with elevated prolactin.

Anabolic-Androgenic Ratio

The anabolic-androgenic ratio is a way to compare a steroid's muscle-building properties (anabolic) to its masculinizing properties (androgenic), with testosterone serving as the baseline at 100:100.

Mibolerone has an extremely high and disproportionate anabolic-to-androgenic ratio. While specific numbers can vary based on the method of measurement, it is often cited as being around 41:160. This indicates that it is an exceptionally powerful anabolic agent but is also extremely androgenic, making it particularly dangerous in terms of masculinizing side effects.