Methyltrienolone

Methyltrienolone, also known as metribolone or by its developmental code name R1881, is an extremely potent synthetic anabolic-androgenic steroid (AAS). It's a derivative of trenbolone and was developed in the late 1960s but was never marketed for medical use due to its high toxicity. It has since been used in scientific research, particularly for studying androgen receptors.

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Side Effects and Benefits

Due to its high toxicity, methyltrienolone has no established medical or therapeutic benefits for humans. It was investigated for breast cancer treatment but was quickly discontinued because it caused severe hepatotoxicity (liver damage) at very low doses. In non-medical contexts like bodybuilding, it's known for its extremely potent anabolic effects, which can lead to significant muscle and strength gains.

However, the cons heavily outweigh the pros. Side effects include:

• Severe hepatotoxicity: This is the most significant risk. It can cause serious, irreversible liver damage.

• Cardiovascular issues: Like other AAS, it can negatively impact cholesterol levels, increase blood pressure, and cause other heart-related problems.

• Virilization: In women, it can cause masculinizing effects like a deeper voice, hair growth, and clitoral enlargement.

• Suppression of natural hormone production: It can completely shut down the body's natural testosterone production, leading to testicular atrophy and infertility.

• Gynecomastia: Due to its progestogenic activity, it can cause breast tissue growth in males.

• Behavioral changes: It can lead to increased aggression, mood swings, and other psychological effects.

Dosage and Frequency

There is no medically established or safe dosage for methyltrienolone. Its use is not recommended due to the extreme risk of liver damage and other side effects.

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Half-Life and Detection Time

The half-life of methyltrienolone is not well-documented, but a study on androgen receptors suggests it may be around 6.6 hours. However, its metabolites can be detected in urine for an extended period. The detection window is generally long, with some sources indicating it can be detected for several months. This is a common characteristic of many oral anabolic steroids, which are often designed to be resistant to breakdown by the liver, thus remaining in the body longer.

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Sterogenic, Progestogenic, and Prolactin Effects

• Androgenic/Anabolic Effects: Methyltrienolone is one of the most potent AAS ever synthesized. Its anabolic-to-androgenic ratio is estimated to be around 120-300:60-70 when compared to methyltestosterone, making it significantly more anabolic than androgenic. This is why it's highly sought after for its muscle-building properties, despite the high risks.

• Progestogenic Effects: It has a high affinity for the progesterone receptor, which contributes to its strong progestogenic effects. This can lead to side effects like gynecomastia, water retention, and mood changes.

• Prolactin Effects: Due to its progestogenic activity and high binding affinity to receptors, it can indirectly lead to an increase in prolactin levels. Elevated prolactin can cause symptoms like lactation in males and females (galactorrhea) and further contribute to gynecomastia.