Cardarine (GW-501516)

Cardarine (GW-501516), also known as Endurobol, is a synthetic chemical that was developed to address metabolic diseases like obesity, diabetes, and cardiovascular issues. It is a peroxisome proliferator-activated receptor-delta (PPARδ) agonist, not a SARM.

Side Effects and Benefits

Benefits:

• Increased Endurance: By promoting the use of fat for energy instead of carbohydrates, Cardarine can significantly enhance physical endurance. This allows for longer and more intense workouts.

• Fat Loss: It is believed to mimic the metabolic effects of exercise, potentially leading to fat loss even without a strict diet or intense physical activity.

• Improved Lipid Profile: Early research suggested that it could help regulate blood lipid levels, such as cholesterol and triglycerides, which could be beneficial for those with dyslipidemia.

Side Effects:

• Cancer Risk: The most critical side effect is the potential for rapid and widespread cancer growth. Animal studies led to the discontinuation of human clinical trials because they showed a high incidence of tumors in various organs, including the liver, thyroid, tongue, and stomach.

• Unknown Long-Term Human Effects: Since human trials were halted, the long-term effects of Cardarine on people are not known.

Pros and Cons

Pros:

• Potential for significant increases in endurance and fat loss.

• Does not act as a steroid or SARM, so it does not directly disrupt hormonal balance in the same way.

Cons:

• High Cancer Risk: The documented risk of cancer in animal studies is a major safety concern.

• Banned Substance: It is prohibited by major anti-doping agencies like the World Anti-Doping Agency (WADA) and is not approved for human consumption.

• Lack of Human Data: There is no long-term human data to confirm its safety or effectiveness.

Dosage and Frequency

There is no medically approved dosage for Cardarine. Anecdotal dosages seen on unregulated markets typically range from 10mg to 20mg per day.

Half-Life and Detection Time

• Half-Life: The half-life is approximately 24 hours, making a once-daily dosage sufficient.

• Detection Time: While the compound itself is metabolized relatively quickly, its metabolites can be detected in urine for up to 40 days or longer. Hair follicle tests can detect it for up to six months.

Sterogenic, Progestogenic, and Prolactin Effects

Cardarine is a PPARδ agonist, and it does not interact with sex hormone receptors. Therefore, it does not have sterogenic, progestogenic, or prolactin effects. It does not mimic or alter natural sex hormone levels.

Anabolic-Androgenic Ratio

Cardarine does not have an anabolic-androgenic ratio. This ratio is used to measure the effects of anabolic-androgenic steroids (AAS). Since Cardarine is not an AAS and does not affect androgen receptors, this ratio is not applicable.